Ian James Selected Research

UK279276

1/2006	Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development : a case study of a therapeutic protein.
8/2005	Bridging the pharmacokinetics and pharmacodynamics of UK-279,276 across healthy volunteers and stroke patients using a mechanistically based model for target-mediated disposition.

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Ian James Research Topics

Disease

11	Multiple Sclerosis 01/2016 - 01/2010
10	Infections 01/2021 - 01/2009
7	Neoplasms (Cancer) 01/2022 - 11/2005
6	Hypersensitivity (Allergy) 06/2020 - 03/2004
5	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2017
5	HIV Infections (HIV Infection) 01/2016 - 04/2008
5	Inclusion Body Myositis 01/2013 - 02/2008
4	Demyelinating Diseases (Demyelinating Disease) 01/2011 - 01/2010
3	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2017
3	Cognitive Dysfunction 01/2018 - 01/2017
3	Dementia (Dementias) 10/2017 - 02/2002
3	Disease Progression 05/2012 - 12/2004
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 09/2017
2	Drug Hypersensitivity Syndrome 01/2019 - 03/2004
2	Autoimmune Diseases (Autoimmune Disease) 09/2017 - 08/2012
2	Disease Susceptibility (Diathesis) 09/2012 - 11/2009
2	Pain (Aches) 01/2006 - 01/2006
2	Ischemia 01/2006 - 01/2006
2	Dysmenorrhea (Menstrual Pain) 01/2006 - 01/2006
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2022
1	Venous Thromboembolism 11/2021
1	Thrombophilia 11/2021
1	Tuberculosis (Tuberculoses) 01/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2020
1	Eosinophilia 01/2019
1	Diarrhea 10/2018
1	Neuroinflammatory Diseases 01/2018
1	Carcinoma (Carcinomatosis) 09/2017
1	Drug-Related Side Effects and Adverse Reactions 09/2017
1	Thrombocytopenia (Thrombopenia) 09/2017
1	Herpes Genitalis (Genital Herpes) 12/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2016
1	Epstein-Barr Virus Infections 01/2016
1	Drug Hypersensitivity (Drug Allergy) 05/2015
1	Epilepsy (Aura) 03/2015

Drug/Important Bio-Agent (IBA)

11	HLA-DRB1 Chains (HLA DRB1)IBA 09/2012 - 01/2005
10	HLA Antigens (Human Leukocyte Antigens)IBA 01/2021 - 10/2009
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2006
7	lumretuzumabIBA 01/2019 - 02/2016
4	Monoclonal AntibodiesIBA 01/2019 - 02/2016
4	HLA-B Antigens (HLA-B)IBA 10/2007 - 03/2004
3	abacavir (Ziagen)FDA Link 06/2020 - 03/2004
3	ErbB Receptors (EGF Receptor)IBA 01/2019 - 10/2017
3	HLA-DR Antigens (HLA-DR)IBA 08/2012 - 05/2002
3	Pharmaceutical PreparationsIBA 01/2009 - 01/2006
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 10/2018
2	HLA-A Antigens (HLA-A)IBA 01/2019 - 12/2004
2	pertuzumabIBA 10/2018 - 01/2017
2	Amyloid (Amyloid Fibrils)IBA 01/2018 - 10/2017
2	Proteins (Proteins, Gene)FDA Link 09/2017 - 02/2016
2	Messenger RNA (mRNA)IBA 09/2017 - 09/2007
2	AntigensIBA 01/2016 - 01/2005
2	AutoantibodiesIBA 08/2012 - 03/2010
2	EpitopesIBA 10/2009 - 10/2007
2	Maraviroc FDA Link 01/2009 - 04/2008
2	CytokinesIBA 01/2008 - 10/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2006 - 03/2004
2	Interleukin-6 (Interleukin 6)IBA 10/2006 - 11/2005
2	Antipsychotic Agents (Antipsychotics)IBA 04/2006 - 02/2002
2	Vasopressins (Vasopressin)IBA 01/2006 - 01/2006
2	UK279276IBA 01/2006 - 08/2005
1	glofitamabIBA 01/2022
1	Estradiol (Delestrogen)FDA LinkGeneric 11/2021
1	Thromboplastin (Tissue Factor)IBA 11/2021
1	Superoxide Dismutase-1IBA 08/2020
1	HLA-B57 antigenIBA 06/2020
1	CholesterolIBA 01/2020
1	HDL LipoproteinsIBA 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2019
1	ParaffinIBA 01/2019
1	Formaldehyde (Formol)FDA Link 01/2019
1	Carboplatin (JM8)FDA LinkGeneric 01/2019
1	Vancomycin FDA LinkGeneric 01/2019
1	Loperamide (Imodium)FDA LinkGeneric 10/2018
1	Antiviral Agents (Antivirals)IBA 08/2018
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2018
1	KynurenineIBA 01/2018
1	tau Proteins (tau Protein)IBA 10/2017
1	histidine-rich proteinsIBA 09/2017
1	Cetuximab (Erbitux)FDA Link 09/2017
1	Neuregulin-1 (Neuregulin 1)IBA 09/2017
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 09/2017
1	Heparin (Liquaemin)FDA LinkGeneric 09/2017
1	KIR ReceptorsIBA 09/2017
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2017
1	Fulvestrant (Faslodex)FDA Link 01/2017
1	Blood Proteins (Serum Proteins)IBA 01/2017
1	Estrogen ReceptorsIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 12/2016
1	Lipopolysaccharide ReceptorsIBA 01/2016
1	Penicillins (Penicillin)FDA Link 05/2015
1	beta-LactamsIBA 05/2015
1	gamma-Aminobutyric Acid (GABA)IBA 03/2015
1	Immunoglobulin E (IgE)IBA 03/2015
1	Viral ProteinsIBA 08/2013

Therapy/Procedure

4	Therapeutics 01/2019 - 04/2009
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/2006 - 05/2002
2	Injections 01/2006 - 01/2006
1	Organ Transplantation 08/2018
1	Drug Therapy (Chemotherapy) 07/2018